Perbedaan Pengaruh Parasetamol dan Parecoxib Terhadap Aktivitas Agregasi Trombosit pada Pasien SIRS atau Sepsis
Background: Paracetamol and Parecoxib are the most widely used non-steroidal anti-inflammatory drugs (NSAIDs) in patients treated with SIRS or ICU sepsis as antipyretics and anti-inflammatory drugs. Both of these drugs can affect platelet aggregation tests.
Purpose: Platelet aggregation and parecoxib on platelet aggregation activity in SIRS or sepsis patients. this was an experimental study with a clinical trial approach with a research design post . There were 34 subjects of SIRS or sepsis patients who had ICU with ages between 17-65 years. Subjects with paracetamol and 17 subjects with parecoxib. After randomization, 120 minutes after treatment, platelet aggregation was examined before treatment using 10 µM ADP inductors.
Results: A score of p = 0.310 in the unpaired group received , which means that there is a significant difference in platelet aggregation between paracetamol and parecoxib groups before treatment and the value of  = 0.013 ( p <0.05), which means that there is a significant difference between the paracetamol and parecoxib groups after treatment. Further analysis of the different test of the Wilcoxon in the paired group received a value of 0.02010 = 0.020 (1945-1910) <0.05) which means that there are significant differences between before administration of paracetamol.
Conclusion: The use of paracetamol will have a statistically significant decrease in platelet aggregation compared to parecoxib (p. 19459010) = 0.013).