Karya Tulis Jurnal Gambaran Hematologi Pasien Myelodysplastic Syndrome di RSUP Dr. M. Djamil Padang
Myelodysplastic syndrome (MDS) is a clonal disorder of stem cells consisting of cytopenia, dysplasia, and possibly transformed into acute myeloid leukemia. The diagnosis of MDS is made through hematological examination, peripheral blood cells, bone marrow, cytogenetic examination and immunophenotyping, but these last two examinations are not available in all hospitals in Indonesia. MDS at Dr. RSUP M. Djamil Padang, is a descriptive study in the central laboratory of Dr. RSUP M. Djamil Padang from November 2016 to October 2017. The population was all patients who underwent bone marrow examination. The study sample was all patients who had been diagnosed with MDS from hematological examination, preparations for removal of peripheral blood and bone marrow. There were 19 MDS sufferers consisting of 52.6% males and 47.4% females, with participation of 1.1: 1; average age of 40.6 years. Physical examination results: anemia 68.4%, anemia + organomegaly 31.6%. Hematological examination: anemia + leukopenia + thrombocytopenia 57.8%, anemia + leukopenia 21.1%, anemia + thrombocytopenia 21.1%. Examination of peripheral blood eradication: erythocyte picture, size: anisopoikilositosis 73.6%, normocytic 26.4%; color: polychrome 57.8%, normochrome 42.2%, found explosion in 42.1% of patients. Examination of bone marrow, cellular preparations: hypocellular 73.6%, hypercellular 21.1%, normocellular 5.3%. Erythrophythmic + granulopoietic + thrombopoietic dysplasia 47.4%; erythropoetic + granulopoietic series 31.5%; erythropoietic + thrombopoietic series 15.8%; erythropoetic series alone 5.3%. The most hematological features of MDS patients in this study were anemia, anisopoicilocytosis, polychrome, hypocellular provider, and the discovery of erythropoetic, granulopoietic and thrombopoietic series.