Jurnal Internasional Stomat somatosensori frekuensi tinggi di dystonia: Bukti untuk plastisitas inhibitor yang tidak efektif – Erro – – Gangguan Gerakan

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Jurnal Internasional Stomat somatosensori frekuensi tinggi di dystonia: Bukti untuk plastisitas inhibitor yang tidak efektif – Erro – – Gangguan Gerakan

Background [19459]: Regardless of motor symptoms, some sensory process deficits have been demonstrated in dystonia. The most consistent behavioral measure of this is the threshold of abnormal somatosensory temporal discrimination, which has recently been associated with physiological measures of reduction in inhibition in the primary somatosensory area. High-frequency sensory stimulation is patterned electrical stimulation applied to the skin through surface electrodes that has recently been reported to shorten somatosensory temporal discrimination in healthy subjects and to increase resting levels of stimulation in various types of inhibitory interactions in somatosensory and even motor areas. ]

Purpose : We examine whether high-frequency sensory stimulation can increase cortical inhibition and, in turn, correct somatosensory temporal discrimination in cervical dystonia.

Method : Temporary somatosensory discrimination and a number of electrophysiological measurements of sensorimotor inhibition and facilitation were measured before and after 45 minutes of repeated high-frequency sensory stimulation.

Results : Compared to a group of healthy volunteers of the same age, among whom high frequency recurrent sensory stimulation increases somatosensory inhibition and shortening while discrimination, patients with cervical dystonia show a consistent response, paradoxically: they have reduced suppression of potential arousing somatosensory pairs of pulses, as well as reducing high frequency oscillations, lateral inhibition, and short interval intracortical inhibition. Somatosensory temporary discrimination deteriorates after the stimulation protocol, and correlates with a reduction in the size of inhibition in the primary somatosensory cortex.

Conclusions: We suggest that patients with dystonia have abnormal homeostatic inhibition plasticity in the sensorimotor cortex and that this is responsible for their paradoxical response to high frequency recurrent sensory stimulation. © 2018 International Parkinson and Disorder Society Movement

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