Jurnal Internasional Penentuan Flowcytometric Neutrophil CD64 (nCD64) pada Anak dengan Community Acquired Pneumonia

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Jurnal Internasional Penentuan Flowcytometric Neutrophil CD64 (nCD64) pada Anak dengan Community Acquired Pneumonia

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Introduction: CD64 expression in neutrophils (nCD64) has shown usefulness in the diagnosis of sepsis. The aim of our study was to evaluate the diagnostic value of CD64 neutrophils in pneumonia as an early marker of infection and correlate its level with the outcome of pneumonia. Methods: Forty children diagnosed as pneumonia and treated in the pediatric department, Minia University Children's Hospital, Egypt, were included in this study and forty children who appeared to be healthy acted as controls. Both patients and controls were targeted for complete blood count (CBC), quantitative C-reactive protein (CRP), arterial blood gas (ABG), and determination of CD64 expression in neutrophils by flowcytometry. Results: The absolute number of nCD64 in patients with community-acquired pneumonia was (1140 ± 109.7) (RFU), significantly higher than controls (327.3 ± 25.7) (RFU) (p = 0.001). Significant positive correlation was found between CD64 and CRP (p = 0.001, r = 0.76) and total leukocyte count of patients (p = 0.01, r = 0.76). A significant negative correlation between CD64 and platelet counts (p = 0.008, r = – 0.7), age and weight (p = 0.001, r = – 0.9) t (p = 0.01, r = – 0 , 8) each. Conclusion: Determination of CD64 peripheral blood neutrophils is sensitive and specific for early diagnosis of pneumonia and high levels associated with clinical decline and poor outcomes.

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