Jurnal Internasional Neutrofil dan NET dalam memodulasi peradangan akut dan kronis

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Jurnal Internasional Neutrofil dan NET dalam memodulasi peradangan akut dan kronis

Abstract

Neutrophils are a very important part of the innate immune system, play an important role in the control of infectious diseases but have recently also been seen as an important player in tissue repair. Neutrophils are able to ward off infections through phagocytosis and / or release of extracellular neutrophil traps (NET). Conversely, neutrophils help repair damaged tissue, limiting NET production but still in the form of phagocytic debris. However, when recurrent inflammation, or instigating agents persist, neutrophils through the inability of frustration to resolve problems can release NET to worsen tissue damage during improper inflammation. In this review, we discuss the mechanism of the formation of NET, as well as the paradoxical role of neutrophils and NET in host defense, chronic inflammation, and tissue damage.

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