Jurnal Internasional miR-150 downregulation berkontribusi pada transformasi limfoma folikuler bermutu tinggi dengan meningkatkan level FOXP1
Follicular lymphoma (FL) is a common indolent B-cell malignancy with variable clinical courses. An unfortunate event in its journey is histological transformation to high-level lymphoma, usually diffuse large B-cell lymphoma. Recent studies show that genetic deviations from MYC or overexpression are related to FL (tFL) transformation. However, the exact molecular mechanism underlying TFL is unclear. Here we carried out the first profile of microRNA expression (miRNAs) in samples of FL and tFL pairs and identified 5 miRNAs as differentially expressed. We focus on one of these miRNAs, namely miR-150 which was uniformly derived in all tFLs examined (~ 3.5 times), and observed that the high level of the MYC was responsible for oppressive miR – 150 in tFL by binding in the upstream area. This MYC-mediated emphasis miR-150 in cell B does not depend on LIN28A / B protein, which affects the maturation of the precursors (19459858) pri-miR-150 ) in myeloid cells. We also show that the low rate of miR-150 in the level of tFL causes an increase in the regulation of targets, namely the protein FOXP1, which is known as a positive regulator for cell survival, as well as B-cell receptors and NF-B signaling in B cells that malignant. We reveal that the low level of miR-150 and its high target level, FOXP1, are associated with shorter overall survival in FL and indicate that miR-150 could function as a well-measured biomarker in paraffin-fixed paraffin-fixed networks. Overall, our study shows the role of MYC / miR-150 / FOXP1 axis in dangerous B cells as a determinant of FL aggressiveness and high-level transformation.