Jurnal Internasional Inisiasi IgM Polyreactive melengkapi aktivasi oleh PF4 / heparin kompleks melalui jalur klasik

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Jurnal Internasional Inisiasi IgM Polyreactive melengkapi aktivasi oleh PF4 / heparin kompleks melalui jalur klasik

Abstract

The mechanism by which exposure to heparin initiates an antibody response in many, if not most, recipients is not well understood. We have recently shown that antigenic platelet factor 4 (PF4) / heparin complex activates complement in plasma and binds to cell B. Here, we explain how this process began. We observed broad stable variations in complement activation when PF4 / heparin was added to healthy donor plasma, indicating respondents “phenotype” (high, medium, or low). Plasma proteomic analysis of healthy donors shows a strong correlation between complement activation and plasma immunoglobulin M (IgM) levels ( r [19459006=0898; P <.005 tetapi="" bukan="" ig="" lainnya.="" isotipe.="" respons="" aktivasi="" komplemen="" terhadap="" pf4="" heparin="" dalam="" plasma="" yang="" menunjukkan="" fenotipe="" donor="" rendah="" ditingkatkan="" dengan="" menambahkan="" igm="" gabungan="" dari="" sehat="" tidak="" monoklonal.="" menipisnya="" generasi="" c3c="" dibatalkan="" oleh="" heparin.="" fitur="" aktivasi-komplemen="" kemungkinan="" dimediasi="" nonimmune="" atau="" natural="" sebagai="" darah="" tali="" pusat="" dan="" monoclonal="" polyreactive="" menghasilkan="" adanya="" memfasilitasi="" deposisi="" antigen="" pada="" sel="" b="" in="" vitro="" pasien="" menerima="" antibodi="" anti-c1q="" mencegah="" kompleks="" keterlibatan="" jalur="" klasik.="" studi-studi="" ini="" bahwa="" variabilitas="" kadar="" berkorelasi="" respon="" fungsional="" untuk="" mengikat="" memicu="" klasik="" mempromosikan="" b.="" memberikan="" wawasan="" baru="" ke="" evolusi="" imun="" trombositopenia="" diinduksi="" dapat="" biomarker="" risiko.=""/>

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