Jurnal EFEKTIVITAS DAN KEAMANAN ANTIKOAGULAN PADA SINDROMA KORONER AKUT TANPA ELEVASI SEGMEN ST

Jurnal EFEKTIVITAS DAN KEAMANAN ANTIKOAGULAN PADA SINDROMA KORONER AKUT TANPA ELEVASI SEGMEN ST

Abstract : Coronary syndrome
acute (SKA) caused by an imbalance between the supply of oxygen with
the need for oxygen in the myocardium. Anticoagulant therapy on the SKA may reduce
cardiovascular events, but also strongly associated with risk
bleeding. This study aims to determine the differences in effectiveness and
the safety of anticoagulant fondaparinux versus enoxaparin in the SKA without
ST segment elevation. This study used a cohort design. Data collected
retrospectively from medical records from January 2012 to December 2013.
The subjects of the study were SKA patients without ST segment elevation that met
inclusion and exclusion criteria. The number of subjects as many as 120 patients divided into
in two groups. Data were analyzed descriptively, quantitatively, and
statistics using Chi-square test. The end result of effectiveness (which patients
not having myocardial infarction or
ischemic recurrence) occurred in 45 patients (75%) in the fondaparinux group and
40 patients (66.7%) in the enoxaparin group (p = 0.315; RR = 1.125; 95% CI
0.893-1.417). There were no significant differences in effectiveness of fondaparinux
and enoxaparin (p> 0,05). Security end result (patients who do not
experienced minor bleeding) occurred in 49 patients (81.7%) in the group
fondaparinux and 39 patients (65%) in the enoxaparin group (p = 0.039; RR = 1.256;
95% CI 1.007-1.567). There are significant differences in fondaparinux security
and enoxaparin (p value <0.05). Major bleeding not found on the fondaparinux and enoxaparin groups. The effectiveness of fondaparinux is the same as enoxaparin, but fondaparinux safety is better than enoxaparin in patients with SKA without ST segment elevation

Keywords : SKA without elevation
segment ST, enoxaparin, fondaparinux

Author : Dina Catur Hapsari

Journal Code: jpfarmasidd140592



Related Articles:

Download Disini